ParkinsonCanadaV1, Main, Exploration, bibRecord, 001543

Common variants at 12ql5 and 12q24 are associated with infant head circumference

Identifieur interne : 001543 ( Main/Exploration ); précédent : 001542; suivant : 001544

Common variants at 12ql5 and 12q24 are associated with infant head circumference

Auteurs : H. Rob Taal [Pays-Bas] ; Beate St Pourcain [Royaume-Uni] ; Elisabeth Thiering [Allemagne] ; Shikta Das [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas, Qatar] ; Nicole M. Warrington [Australie, Canada] ; Marika Kaakinen [Finlande] ; Eskil Kreiner-Moller [Danemark] ; Jonathan P. Bradfield [États-Unis] ; Rachel M. Freathy [Royaume-Uni] ; Frank Geller [Danemark] ; Monica Guxens [Espagne] ; Diana L. Cousminer [Finlande] ; Marjan Kerkhof [Pays-Bas] ; Nicholas J. Timpson [Royaume-Uni] ; Marfan Ikram [Pays-Bas] ; Lawrence J. Beilin [Australie] ; Klaus Bonnelykke [Danemark] ; Jessica L. Buxton [Royaume-Uni] ; Pimphen Charoen [Royaume-Uni, Thaïlande] ; Bo Lund Krogsgaard Chawes [Danemark] ; Johan Eriksson ; David M. Evans [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; John P. Kemp [Royaume-Uni] ; Cecilia E. Kim [Pays-Bas] ; Norman Klopp ; Jari Lahti ; Stephen J. Lye [Canada] ; George Mcmahon [Royaume-Uni] ; Frank D. Mentch [États-Unis] ; Martina Müller-Nurasyid ; Paul F. O'Reilly [Royaume-Uni] ; Inga Prokopenko ; Fernando Rivadeneira [Pays-Bas] ; Eric A. P. Steegers ; Jordi Sunyer [Espagne] ; Carla Tiesler [Allemagne] ; Hanieh Yaghootkar [Royaume-Uni] ; Monique M. B. Breteler [Pays-Bas] ; Stephanie Debette ; Myriam Fornage ; Vilmundur Gudnason ; Lenore J. Launer ; Aad Van Der Lugt [Pays-Bas] ; Thomas H. Jr Mosley ; Sudha Seshadri ; Albert V. Smith ; Meike W. Vernooij [Pays-Bas] ; Alexandra I. F. Blakemore [Royaume-Uni] ; Rosetta M. Chiavacci [États-Unis] ; Bjarke Feenstra [Danemark] ; Julio Fernandez-Banet ; Struan F. A. Grant [États-Unis] ; Anna-Liisa Hartikainen ; Albert J. Van Der Heijden [Pays-Bas] ; Carmen Iniguez [Espagne] ; Mark Lathrop ; Wendyl Mcardle

Source :

Nature genetics [ 1061-4036 ] ; 2012.

RBID : Pascal:12-0224069

Descripteurs français

Pascal (Inist)
- Variant, Nourrisson.

English descriptors

KwdEn :
- Infant, Variant.

Abstract

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10-⁹) and rs1042725 on chromosome 12q15 (P = 2.8 x 10^-10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height¹, their effects on infant head circumference were largely independent of height (P = 3.8 x 10^-7 for rs7980687 and P = 1.3 x 10^-7 for rs1 042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10^-6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume², Parkinson's disease and other neurodegenerative diseases^3-5, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

Affiliations:

Allemagne, Australie, Canada, Danemark, Espagne, Finlande, Pays-Bas, Qatar, Royaume-Uni, Thaïlande, États-Unis
Angleterre, Catalogne, Grand Londres, Groningue (province), Hollande-Méridionale, Hovedstaden, Ontario, Pennsylvanie, Uusimaa
Barcelone, Copenhague, Groningue, Helsinki, Londres, Rotterdam, Toronto
Université d'Helsinki, Université de Toronto

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Le document en format XML

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<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
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<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
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<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
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<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
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<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name>
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<author><name sortKey="Ikram, Marfan" sort="Ikram, Marfan" uniqKey="Ikram M" first="Marfan" last="Ikram">Marfan Ikram</name>
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<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
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<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J." last="Beilin">Lawrence J. Beilin</name>
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<author><name sortKey="Bonnelykke, Klaus" sort="Bonnelykke, Klaus" uniqKey="Bonnelykke K" first="Klaus" last="Bonnelykke">Klaus Bonnelykke</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Health Sciences, University of Copenhagen, Copenhagen University Hospital</s1>
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<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
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<s2>London</s2>
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<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1>
<s2>London</s2>
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<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University</s1>
<s2>Bangkok</s2>
<s3>THA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Health Sciences, University of Copenhagen, Copenhagen University Hospital</s1>
<s2>Gentofte</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Netherlands Consortium for Healthy Aging</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E." last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J." last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D." last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
</author>
<author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A. P." last="Steegers">Eric A. P. Steegers</name>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Center for Research in Environmental Epidemiology (CREAL)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Hospital del Mar Research Institute (IMIM)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Centro de Investigación Biomedica en Red en Epidemiologia y Salud Pública (CIBERESP)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>German Research Center for Environmental Health</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1>
<s2>Exeter</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Netherlands Consortium for Healthy Aging</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
</author>
<author><name sortKey="Der Lugt, Aad Van" sort="Der Lugt, Aad Van" uniqKey="Der Lugt A" first="Aad Van" last="Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H Jr" sort="Mosley, Thomas H Jr" uniqKey="Mosley T" first="Thomas H. Jr" last="Mosley">Thomas H. Jr Mosley</name>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Section of Investigative Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M." last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Epidemiology Research, Statens Serum Institut</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>11 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Banet, Julio" sort="Fernandez Banet, Julio" uniqKey="Fernandez Banet J" first="Julio" last="Fernandez-Banet">Julio Fernandez-Banet</name>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Der Heijden, Albert J Van" sort="Der Heijden, Albert J Van" uniqKey="Der Heijden A" first="Albert J. Van" last="Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Paediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iniguez, Carmen" sort="Iniguez, Carmen" uniqKey="Iniguez C" first="Carmen" last="Iniguez">Carmen Iniguez</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Centro de Investigación Biomedica en Red en Epidemiologia y Salud Pública (CIBERESP)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
</author>
<author><name sortKey="Mcardle, Wendyl" sort="Mcardle, Wendyl" uniqKey="Mcardle W" first="Wendyl" last="Mcardle">Wendyl Mcardle</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0224069</idno>
<date when="2012">2012</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common variants at 12ql5 and 12q24 are associated with infant head circumference</title>
<author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H. Rob" last="Taal">H. Rob Taal</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Paediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>German Research Center for Environmental Health</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Paediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Physiology and Biophysics, Weill Cornell Medical College-Qatar</s1>
<s2>Doha</s2>
<s3>QAT</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Qatar</country>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, The University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute of Health Sciences, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Biocenter Oulu, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Health Sciences, University of Copenhagen, Copenhagen University Hospital</s1>
<s2>Gentofte</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M." last="Freathy">Rachel M. Freathy</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1>
<s2>Exeter</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Epidemiology Research, Statens Serum Institut</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>11 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Center for Research in Environmental Epidemiology (CREAL)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Hospital del Mar Research Institute (IMIM)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Centro de Investigación Biomedica en Red en Epidemiologia y Salud Pública (CIBERESP)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name>
<affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Institute for Molecular Medicine Finland, University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Epidemiology, University Medical Center Groningen, University of Groningen</s1>
<s2>Groningen</s2>
<s3>NLD</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ikram, Marfan" sort="Ikram, Marfan" uniqKey="Ikram M" first="Marfan" last="Ikram">Marfan Ikram</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Netherlands Consortium for Healthy Aging</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J." last="Beilin">Lawrence J. Beilin</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>School of Medicine and Pharmacology, The University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bonnelykke, Klaus" sort="Bonnelykke, Klaus" uniqKey="Bonnelykke K" first="Klaus" last="Bonnelykke">Klaus Bonnelykke</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Health Sciences, University of Copenhagen, Copenhagen University Hospital</s1>
<s2>Gentofte</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Section of Investigative Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University</s1>
<s2>Bangkok</s2>
<s3>THA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Health Sciences, University of Copenhagen, Copenhagen University Hospital</s1>
<s2>Gentofte</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Netherlands Consortium for Healthy Aging</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E." last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J." last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D." last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
</author>
<author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A. P." last="Steegers">Eric A. P. Steegers</name>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Center for Research in Environmental Epidemiology (CREAL)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Hospital del Mar Research Institute (IMIM)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Centro de Investigación Biomedica en Red en Epidemiologia y Salud Pública (CIBERESP)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>German Research Center for Environmental Health</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1>
<s2>Exeter</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Netherlands Consortium for Healthy Aging</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
</author>
<author><name sortKey="Der Lugt, Aad Van" sort="Der Lugt, Aad Van" uniqKey="Der Lugt A" first="Aad Van" last="Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H Jr" sort="Mosley, Thomas H Jr" uniqKey="Mosley T" first="Thomas H. Jr" last="Mosley">Thomas H. Jr Mosley</name>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Radiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Section of Investigative Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M." last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Epidemiology Research, Statens Serum Institut</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>11 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Banet, Julio" sort="Fernandez Banet, Julio" uniqKey="Fernandez Banet J" first="Julio" last="Fernandez-Banet">Julio Fernandez-Banet</name>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>51 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Der Heijden, Albert J Van" sort="Der Heijden, Albert J Van" uniqKey="Der Heijden A" first="Albert J. Van" last="Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Paediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iniguez, Carmen" sort="Iniguez, Carmen" uniqKey="Iniguez C" first="Carmen" last="Iniguez">Carmen Iniguez</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Centro de Investigación Biomedica en Red en Epidemiologia y Salud Pública (CIBERESP)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
</author>
<author><name sortKey="Mcardle, Wendyl" sort="Mcardle, Wendyl" uniqKey="Mcardle W" first="Wendyl" last="Mcardle">Wendyl Mcardle</name>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Infant</term>
<term>Variant</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Variant</term>
<term>Nourrisson</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10-<sup>9</sup>
) and rs1042725 on chromosome 12q15 (P = 2.8 x 10<sup>-10</sup>
) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height<sup>1</sup>
, their effects on infant head circumference were largely independent of height (P = 3.8 x 10<sup>-7</sup>
 for rs7980687 and P = 1.3 x 10<sup>-7</sup>
 for rs1 042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10<sup>-6</sup>
). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume<sup>2</sup>
, Parkinson's disease and other neurodegenerative diseases<sup>3-5</sup>
, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Finlande</li>
<li>Pays-Bas</li>
<li>Qatar</li>
<li>Royaume-Uni</li>
<li>Thaïlande</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Catalogne</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Hollande-Méridionale</li>
<li>Hovedstaden</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Uusimaa</li>
</region>
<settlement><li>Barcelone</li>
<li>Copenhague</li>
<li>Groningue</li>
<li>Helsinki</li>
<li>Londres</li>
<li>Rotterdam</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
<li>Université de Toronto</li>
</orgName>
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<tree><noCountry><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
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<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
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<name sortKey="Ikram, Marfan" sort="Ikram, Marfan" uniqKey="Ikram M" first="Marfan" last="Ikram">Marfan Ikram</name>
<name sortKey="Ikram, Marfan" sort="Ikram, Marfan" uniqKey="Ikram M" first="Marfan" last="Ikram">Marfan Ikram</name>
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<name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
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<name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
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   |texte=   Common variants at 12ql5 and 12q24 are associated with infant head circumference
}}

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Common variants at 12ql5 and 12q24 are associated with infant head circumference

Common variants at 12ql5 and 12q24 are associated with infant head circumference

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